Platelet-rich plasma (PRP) is gaining increasing popularity as a non-surgical treatment choice for a wide range of medical conditions. PRP has been extensively utilized in various fields including plastic surgery, dermatology, neurology, and cardiac surgery over the past two decades. More recently, it has also found applications in gynecology and reproductive medicine.
What is PRP?
Platelet Rich Plasma (PRP) treatment is an (autologous) blood fraction with high platelet aggregation. It is a modern treatment in the field of health, which undertakes the activation and strengthening of the body’s natural capacity to regenerate and recreation its tissues and organs.
Following any injury that leads to bleeding, platelets release specific growth factors that regulate the inflammatory response, prevent and combat infections, and facilitate the complete healing and tissue repair process. Autologous PRP treatment focuses on restoring the balance between platelets and red blood cells. This involves reducing the percentage of red blood cells to 5%, as they are less beneficial in the healing process while increasing the concentration of platelets to 94%. As a result, the remaining plasma contains a significantly higher concentration of growth factors (such as PDGF, TGF-Β1, TGF-Β2, PDEGF, PDAF, PF-4, GMP-140, IL-1FGF, ILGF) compared to whole blood, further promoting the healing response.
Consequently, the administration of PRP to a specific area of the body directly stimulates cellular regeneration. Women experiencing premature menopause or those with limited or no response to IVF medication in their pursuit of conception may find potential benefits from PRP treatment. The objective is to revitalize their ovaries, thereby enhancing their ability to produce viable eggs.
Candidates for treatment with PRP
- Women with premature ovarian failure
- Women who are poor responders during IVF treatment with low ovarian reserve and low AMH(antimullerhian hormone)
- Women with early perimenopause
- Women with repeated implantation failures and thin endometrium(less than 7mm).In these cases we insert PRP inside the uterine cavity before embryo transfer.
Is it safe for the woman?
PRP is derived from a woman’s blood, therefore there is no danger of transmission of infectious diseases and allergic reactions.
How is PRP injected into the ovaries?
In amenorrheic women, it can be performed at any time. Women who have periods usually have this procedure performed in the first days of the cycle.
1) First, we extract 10 ml of blood . Blood is then centrifuged to separate white blood cells and platelets from red blood cells.
2) Once PRP has been prepared, is injected into the ovaries transvaginally like in oocyte retrieval.
This particular procedure is conducted with the administration of mild sedation and typically takes approximately 20 minutes to complete. Following the treatment, the woman is free to resume her normal daily activities. Subsequently, she undergoes regular monitoring through hormonal tests (FSH, LH, AMH) and ultrasound examinations every four weeks over a span of six months to assess the effectiveness of the PRP treatment.
At our clinic, we have successfully implemented PRP in specific cases, yielding highly favorable outcomes.